Glossary entry (derived from question below)
English term or phrase:
housekeeping gene
Italian translation:
gene housekeeping
Apr 20, 2010 09:54
14 yrs ago
7 viewers *
English term
housekeeping gene
GBK
English to Italian
Medical
Genetics
Definition from
Wikipedia:
A housekeeping gene is typically a constitutive gene that is required for the maintenance of basal cellular function, and are found in all human cells.[1][2] Although some housekeeping genes are expressed at relatively constant levels(such as HSP90 and Beta-actin), other housekeeping genes may vary depending on experimental conditions.
Example sentences:
Here, the non-regulation of seven housekeeping genes (beta-tubulin, cyclophilin, actin, elongation factor 1-alpha (ef1alpha), 18S rRNA, adenine phosphoribosyl transferase (aprt), and cytoplasmic ribosomal protein L2) during biotic (late blight) and abiotic stresses (cold and salt stress) was tested on potato plants using geNorm software. (National Center for Biotechnology Inform)
An inherent assumption in the use of housekeeping genes is that expression of the genes remains constant in the cells or tissues under investigation. Although exceptions to this assumption are well documented, housekeeping genes are of value in fully characterized systems. (American Physiological Society)
The researchers propose that many other housekeeping genes in addition to HPRT may also be found to regulate important developmental pathways. (MediLexicon International Ltd)
Proposed translations
(Italian)
| 5 +2 | gene housekeeping |
Serena Arduini
|
Change log
Apr 19, 2010 22:06: changed "Kudoz queue" from "In queue" to "Public"
Apr 20, 2010 09:54: changed "Stage" from "Preparation" to "Submission"
Apr 23, 2010 10:56: changed "Stage" from "Submission" to "Completion"
Proposed translations
+2
58 mins
Serena Arduini
Ireland
Ireland
Ireland
For the love of science and translation!
Native in: Italian 
Works in: English to Italian
Related KudoZ points
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24
Selected
gene housekeeping
Definition from
Wikipedia :
Si definiscono geni housekeeping dei geni che vengono attivamente trascritti e tradotti ad un livello relativamente elevato. Generalmente, essi codificano per proteine ed enzimi fondamentali per la vita della cellula, e che pertanto devono essere sempre presenti.
Example sentences:
Tuttavia, la selezione dei geni di controllo adatti può causare problemi poiché possono non essere espressi ugualmente attraverso tutti i campioni incogniti. Ciò può essere risolto normalizzando le misure con un insieme di geni housekeeping per evitare tale problema di variabilità. (Wikipedia - PCR Real Time)
Verrà allestito un sistema di PCR quantitativa real-time su cDNA da retrotrascrizione per la quantificazione relativa dei livelli di espressione delle MEP, utilizzando come riferimento il livello di espressione di un gene housekeeping. (Ricerca italiana - PRIN)
La reazione avviene in parallelo per il sistema relativo alla PMP22 e per un gene housekeeping sicuramente presente in copia singola nel genoma, nonché ubiquitariamente espresso. La presenza di quest’ultimo è fondamentale per l’analisi di quantizzazione in Real Time, poiché consente di avere un riferimento di numero di copie geniche. (Tesi - Gabrielli Livide)
4 KudoZ points awarded for this answer.
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