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MILK AND TISSUE RESIDUE DEPLETION
A metabolism study in cattle using radiolabeled ceftiofur provided
the data to establish tolerances for ceftiofur-related residues (as
desfuroylceftiofur) in tissue and milk. These tolerances are 0.1 ppm
in milk, 0.4 ppm in kidney, 2.0 ppm in liver, and 1.0 ppm in muscle.
Two pivotal milk residue decline studies were conducted. In these
studies, non-mastitic cows received 125 mg of ceftiofur per quarter
into all four quarters either twice at a 24-hour interval or once daily
for 8 consecutive days. Regardless of treatment duration and using
a tolerance of 0.10 ppm for ceftiofur-related residues in milk, these
studies demonstrate that milk taken during treatment (a maximum of
8 consecutive daily infusions) and for 72 hours after the last treatment
must not be used for human consumption and must be discarded